Egg donation (egg transferring) process: Egg donation makes the miracle of life possible it is the process by which a woman donates eggs so whereby another woman can conceive.
As such, it is a method of oocytes from a donor, to fulfill the candidates desire of becoming a mother. Egg donors undergo a quick IVF treatment cycle in which the ovaries are stimulated with the same hormone FSH [Follicle-stimulating hormone]. The oocytes from the donor will be combined with spermatozoa from the recipient couple to produce embryos, by fertilizing the eggs which are taken from another individual, suitable for the family, with the sperm from the father placed in the patient’s uterus to achieve the longed for result of a pregnancy. As such egg donation is a third party reproduction as part of assisted reproductive technology and this [Assisted Reproductive Technology] is ART.
Possible egg donation candidates
Women who have never had a period, however, whose uterine mucosa is intact.
Women whose ovum [egg cells] have been damaged due to chemo or radiotherapy
Patients of whom none or a very tiny amount of eggs have been retrieved in previous IVF procedure
Those whose FSH [Follicle-stimulating hormone] levels are above 15 on the third day of menstruation
Patients who have had unsuccessful IVF treatments and couldn’t conceive
Women whose ovary has been removed or who have lost a significant amount of tissue due to surgical operations such as cyst removals
@ Patients with a possible risk of hereditary illnesses.
@ Women whom experience menopause at an early age
Egg donation selection can be a “known” or an “anonymous” donor.
A 'known' donor for Egg Donation
If a woman wants to receive eggs from a known donor, the donor is advisable to be a woman between the ages of 21-30, without medical or genetic condition. Tests in compliance with guideline standards of the European Society of Reproductive Medicine [ESHRE] and the American Society for Reproductive Medicine [ASRM], where all donors are tested for infectious diseases. It is advisable both parties agree and produce an official agreement by an advocate/lawyer.
An 'anonymous' donor for Egg Donation
The meaning of 'anonymous' applies to the discretion of secrecy regarding the identity of both donor and the recipient. Conditions apply to women whom choose to become anonymous donors: A. Average in weight. B. No medical or genetic condition. C. Infectious diseases [according to the ESHRE and ASRM criteria]. D. Restricted to women aged between 21-30.
” A donor can be someone known by the couple or anonymous.
” Donors should be at the age of 21-30 and not have a medical condition.
” Women who have had healthy pregnancies and given birth can become donors.
” Donors shouldn’t be of families with a history of family mental retardation.
” Donors who have a hereditary disease or a family history of such are not accepted.
Screening tests applied to egg donors
1. The donor fills in a 'profile form'.
2. Our specialist medical committee make the first assessment and examination.
3. Donors are people who have been assessed for infectious diseases [HIV, hepatitis B and C, cytomegalovirus, syphilis, chlamydia], genetic diseases [karyotype analysis and cystic fibrosis screening]; their blood type and Rh factor tests completed and those of specific ethnic background who have had thalassemia and drepanocytic anemia tests.
4. Cervical culture tests are undergone regarding Gonorrhea, Chlamydia, Ureaplasma and Mycoplasma.
When the time comes to selecting the donor, you can be sure the utmost care is given to match the physical features such as the color of the skin, eyes, hair and body type, build of both the donor and the recipient to as identical as possible. In addition, it is standard procedure their ethnic origin, blood type and other physical features are tried to be kept as identical as possible to the recipient couple.
* Both the donor’s and the recipient’s identities are kept confidential.
* A consent form is signed prior to the treatment by both the donor and the recipient. Donors are asked to sign an informed consent form stating that their eggs will be used to produce embryos and that those will be frozen and stored.
Tests are required for the recipient couple who are due to receive eggs from donors
1. Initially, the couple is assessed and examined by one of our specialists, their medical records evaluated.
2. The female partner is examined by our specialists in order to be sure that her medical condition is healthy and in check.
3. Rubella immunity, blood type, HIV antibody, hepatitis B and C, surface antigen, RPR for cyphilis tests are carried out on the female partner. Cervical culture tests are undergone for Cytomegalovirus [CMV], Gonorrhea, Chlamydia, Ureaplasma, Urealyticum and Mycoplasma Hominis.
4. If in the last two years, hysterosalpingography and hysteroscopy has not been carried out, it is carried out to see if the uterine cavity is in good health.
5. The male partner, his blood type, HIV antibody, Hepatitis B and C surface antigen, RPR and CMV for cyphilis tests are required.
6. If in the last 6 months, semen analysis has not been carried out, this is also required.
Egg Donation Treatment Period:
The total timescale for treatment in North Cyprus is 5 days. The duration of the egg donation process, medication is given to the donor and the recipient so that their periods are simultaneous. As soon as the donor starts with the treatment to grow eggs, the recipient starts taking estrogen on the second day of her menstruation. Estrogen assists the intrauterine tissue, on which the transferred embryos are going to be attached, to thicken.
This is a pre-treatment phase, lasts for about 12 days. It is a process the patients concerned are able to apply in their hometown/country due to the fact it involves taking pills as medication. Following this period, the patients require to make travel plans to the North Cyprus, whereby on the day the eggs are retrieved from the donor, sperm is taken from the patient’s male partner and via microinjection fertilization starts.
On the same day, the mother-to-be starts with the vaginal progesterone. Following the day of sperm collection, 3-5 days later the treatment is completed by transferring 2 or 3 embryos into the uterus.
12 days after the operation, BHCG levels are checked from the blood for pregnancy diagnosis. If the couple so wishes, it is possible fertilized eggs and/or embryos which have shown a healthy growth can be frozen and stored for the couple to use in the future.
Results and success rates.
Pregnancy rates with egg donation are quite high; higher than the rates of pregnant couples whose own sperm and eggs are used. These success rates are due to the donors not having any infertility related condition and because they can produce healthier eggs compared to infertile patients. In addition, the patient’s endometrium does not encounter any hyperstimulation and thus, becomes fitter for implantation. For these reasons, it is usual practice for three donated embryos to be transferred at once.
Gyneacologist surgeon specialist Tolga TUNA and her team have a success rate of 60-70% in these types of procedures.